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New Generation Trans-resveratrol -grape Skin Extracts Pterostilbene

Resveratrol (3,5,4’-trihydroxy-trans-stilbene),is a stilbenoid, a type of natural phenol. As one of popular anti-aging supplements, was discovered in 1963, when it was found in Japanese Knotweed.Now sources of resveratrol naturally from knotweed ,grapes skin,etc. Pterostilbene...

Resveratrol (3,5,4’-trihydroxy-trans-stilbene),is a stilbenoid, a type of natural phenol. As one of popular anti-aging supplements, was discovered in 1963, when it was found in Japanese Knotweed.Now sources of resveratrol naturally from knotweed ,grapes skin,etc.

Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a stilbenoid chemically related to resveratrol, is the main antioxidant component of blueberries,and Pterocarpus marsupium heartwood. Some studies suggest it may be more useful for health than its close relation , so it may be as a super resveratrol.




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98%min white powder

99%white powder

Related products:

Natural Resveratrol;
grape skin extract powder;
Micronized Resveratrol Powder;
Water-soluble resveratrol;

Natural Pterostilbene;


Trans-Pterostilbene Disodium

Difference between Pterostilbene and Resveratrol

Pterostilbene and resveratrol both have the same role in the plant’s defense system. “Resveratrol is one of the main phytoalexins in grapes, pterostilbene in blueberries,” explained Jeremy Bartos, PhD, pTeroPure product manager for ChromaDex of Irvine, CA. “The only difference between the two is the presence of two methoxy groups in pterostilbene (resveratrol has three hydroxyl groups, pterostilbene has one along with the two methoxys). 

It’s the methoxy groups that make all of the difference when it comes to utilizing these compounds in the human body. “Resveratrol has two things going against it,” said Dr. Bartos. “One is the fact that without the methoxy groups it is not as lipophilic (oil-soluble) as pterostilbene, so it’s cellular uptake is much less than pterostilbene - pterostilbene can be taken through the cell’s lipid bi-layer rather easily.” 


The second difference has to do with how pterostilbene is filtered through the human liver. “The liver acts as the gatekeeper to the body; it filters everything that comes through and compounds it does not recognize (such as pharmaceuticals, plant chemicals and toxins) it will tag for elimination from the body,” said Dr. Bartos. “In the case with stilbenes such as resveratrol and pterostilbene the liver will typically glucuronidate (add a glucuronic acid molecule, a compound very similar to glucose) or sulfate any free hydroxyl groups it can find. Since resveratrol has three hydroxyl groups it is tagged for elimination much quicker and easier than pterostilbene with only one hydroxyl group, leading to a half-life in the blood of ~14 minutes compared to ~105 minutes for pterostilbene.”

Pterostilbene offers the following advantages over resveratrol:

Superior bioavailability  

Significantly longer half-life 

Greater cellular uptake  

Greater oral absorption and metabolic stability

How Pterostilbene and Resveratrol Work Together

Scientists have found that resveratrol activates genes near the beginning of the molecular cascade precipitated by caloric restriction. These in turn activate a broad array of disease-preventing genes. In essence, resveratrol’s beneficial genetic action takes place “upstream”. Pterostilbene directly activates genes “downstream” from the sites of resveratrol’s action. This complements resveratrol’s ability to help prevent cancer and diabetes, and support healthy blood lipids. Acting together, resveratrol and pterostilbene produce potent longevity-promoting effects across the cycle of gene expression through complementary mechanisms.

Where to buy materials of Pterostilbene and Resveratrol powder

Wuxi Cima Science Co.,ltd, with more than 10 years’ experience in researching and producing trans-pterostilbene and trans-resveratrol,is a reliable manufacturer who export bulk quantity to worldwide countries. Documents like certificate of analysis (COA),MSDS,specifications sheet,manufacturing flow chart,GMO-free,etc,available upon your request.


1.Q:Do you offer natural resveratrol extracted from Polygonum cuspidatum?

A:Yes,we offer natural resveratrol from Polygonum cuspidatum, regular specifications 50% and 98%powder. 

2.Q:Is your pterostilbene Trans-Pterostilbene?

A:Yes,all pterostilbene we provided is Trans-Pterostilbene.

3.Q: What assay is your Water-soluble resveratrol?

A:For Water-soluble resveratrol we usually offer 5%-10% powder.

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