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Chronic Nicotinamide Riboside Supplementation

Nicotinamide Riboside- New promising ingredient for supplement What is Nicotinamide riboside (NR) ? Nicotinamide riboside (NR) is a pyridine-nucleoside form of vitamin B 3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+. NAD+ is a key component of the body’s energy...

Nicotinamide Riboside- New promising ingredient for supplement

What is Nicotinamide riboside (NR) ?

Nicotinamide riboside (NR) is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+. NAD+ is a key component of the body’s energy cascade. Like CoQ10 (ubiquinone), it is ubiquitous in all the cells and organs of the body. It declines with aging, physical deconditioning, and disease states. It is essential for efficient energy output of the mitochondria, the powerhouses of the cells.

English Name: Nicotinamide Riboside Chloride

Chemical Name: 3-(Aminocarbonyl)-1-beta-D-ribofuranosyl-pyridinium chloride(1:1)

Chemical Formula: C11H15N2O5.Cl

Molecullar Weight: 290.70

Chemical Family: Vitamin Derivatives

Cas No.: 1341-23-7

How it Works ?

The reason why nicotinamide riboside is such a potent promoter of healthspan and lifespan is because once it enters the body, it converts to one of the most essential factors in energy production in cells, nicotinamide adenine dinucleotide(NAD+).

NAD+ has two key functions in the body that help combat aging. First, it enhances cellular energy by boosting the function of mitochondria, the body’s cellular “power plants” that convert the food we eat into energy our bodies can use.3 While age-related mitochondrial dysfunction can result in tissue and organ failure, studies show that restoring mitochondrial function slows aging and extends longevity.

Second, NAD+ activates enzymes called sirtuins that control gene expression. SIRT enzymes “turn off” certain genes that promote aging, such as those involved in inflammation,in fat synthesis and storage, and in blood-sugar management.

By boosting the body’s levels of NAD+, nicotinamide riboside helps protect the body against some of the most potent age-accelerating processes that threaten longevity. Three of these disorders include obesity, nonalcoholic fatty liver disease, and cognitive decline.

What benefits you can get from taking nicotinamide riboside ?

Boosts NAD+ levels

Cellular age

Protection against cell damage

Support aging of skeletal muscle

Resistance to weight gain

Supporting cellular energy and communication

Protecting against noise induced hearing impairment 

Improving Metabolism

Supporting a healthy cardiovascular system 

Elevates Mood 

May improve skin and gives a more youthful appearance 

How about safety of nicotinamide riboside ?

No serious side effects or safety concerns have been identified for nicotinamide riboside. A toxicology report from a supplement manufacturer states that no adverse effects were observed for doses up to 1000 mg/kg in rodents, which is higher than the standard supplement dose . One eight-week study in elderly people reported no serious adverse effects using a combination of nicotinamide riboside and pterostilbene, although it did increase LDL cholesterol levels in overweight individuals . However, safety has not yet been confirmed in humans, particularly for long-term use.

There are a few theoretical concerns with artificially raising NAD+ levels. Normal NAD+ levels appear to fluctuate naturally throughout the day, so artificially increasing them may disrupt healthy circadian signaling . Additionally, depleting NAD+ levels has been proposed as a treatment for cancer, inflammation, and cardiovascular disease, and one study suggests that NAD+ may accelerate the breakdown of bones . But there is currently no evidence to substantiate these risks with nicotinamide riboside supplementation.

How to use ?

Nicotinamide riboside is available as an over-the-counter dietary supplement. A supplement manufacturer recommends a dose of 100–250 mg taken before the first meal of the day.

Nicotinamide riboside is also available in combination with pterostilbene, an antioxidant that is closely related to resveratrol(e.g., Basis from Elysium Health), at a dose of 250 mg of nicotinamide riboside and 50 mg of pterostilbene per day. Although there is a theoretical rationale for combining the two supplements, no scientific studies have directly tested whether the combination is more effective than nicotinamide riboside alone.

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