Contact Us
Whatsapp: 13912398878
Tel: (+86)0510-8518 8225
Fax: (+86)0510-8518 5685
E-mail: info@cimasci.com
ADD: No.288 Shibawan Road Wuxi,
         Jiangsu, China

Anti-aging Nicotinamide Riboside

A magical molecule Derivatives of vitamin B ——Nicotinamide Riboside What is Nicotinamide Riboside Nicotinamide ribose is found naturally in milk. Other dairy derivatives, such as whey and yeast containing foods, are also considered natural sources of nicotinamide ribose. The nicotinamide ribose...

A magical molecule Derivatives of vitamin B

——Nicotinamide Riboside

What is Nicotinamide Riboside

Nicotinamide ribose is found naturally in milk. Other dairy derivatives, such as whey and yeast containing foods, are also considered natural sources of nicotinamide ribose. The nicotinamide ribose and the molecular structure of vitamin B class is very similar, it is in recent years by scientists found that belongs to a human body can increase in nicotinamide adenine dinucleotide (NAD +) levels of vitamin B3 derivatives.

Latin Name:Nicotiamide Riboside

Alias:Nicotinamide-beta-riboside

Chemical name:1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]

pyridine-5-carboxamide

CAS No.:1341-23-7

Molecular formula :C11H16N2O5

image001.gif


History

·NR was first discovered by scientists in 1944.

·In 2000, yeast Sirt2 was shown to be dependent on nicotinic amide adenine dinucleotide (NAD+) protein, a lysine deacetylase

·In 2016, FDA approved nicotinamide ribose as an accepted safe GRAS food ingredient


Effect

1. Anti-aging:NR can enhance mitochondrial function, which is shown to enhance the expression of mitochondrial electron transport chain proteins, enhance mitochondrial membrane potential, and increase the rate of oxidative respiration and intracellular ATP levels. This may be accompanied by higher levels of mitochondrial regeneration. Mitochondrial function declines as we age, and this is the sign of the aging of stem cells that we find. NR can enhance the function of mitochondria and inhibit the senescence of stem cells.

2.Reduce weight: Studies have shown that by increasing energy metabolism, you can effectively reduce the high-fat diet induced weight gain. In order to evaluate the nicotinamide ribose mechanism of NR promoting weight loss, the researchers measured the liver mitochondrial function associated with caloric intake, activity, calories, waist circumference, resting metabolic rate, body composition, glucose tolerance, insulin sensitivity and various biochemical and metabolomics parameters. These data and the new weight loss mechanism by malabsorption, excretion of biological markers for tracking. The researchers reported that mice fed nicotinamide nicotinamide (NR) supplements were significantly more likely to lose weight relative to mice that did not supplement nicotinamide.

3.Diabetes reduction:The researchers noted that in the study, there was evidence that supplementation of nicotinamide ribose (NR) improved metabolic health in mice fed an excessive amount of food. They also pointed out that research has shown that nicotinamide ribose NR has the ability to protect damaged neurons. Because of this dual potential, the researchers concluded that nicotinamide ribose NR could improve glucose and lipid metabolism in prostate (PD) and diabetes, while simulating neurological complications associated with the treatment of DPN. However, further studies and data are needed, such as the use of lower doses in obese people for clinical trials for type 2 diabetes and related neuropathy.


Action mechanism

image003.jpg

Studies have shown that once nicotinamide ribose appears in the cell, the body rapidly transforms it into NAD+. These NAD+ then stimulate the process of intracellular initiation of energy production by mitochondria

 

Advantages among peers

image005.jpg

Preclinical studies have shown that the addition of nicotinamide ribose can not only increase NAD+ levels safely, but also maximize the utilization of NAD+ in humans, which is not possible with other vitamin B3.

Hot Tags: anti-aging nicotinamide riboside, suppliers, manufacturers, wholesale, price, buy, custom, for sale
Inquiry